G10 [PMID: 26646986]

Ligand id: 9206

Name: G10 [PMID: 26646986]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 87.85
Molecular weight 430.06
XLogP 3.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[(2-chloro-6-fluorophenyl)methyl]-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxamide
Database Links
PubChem CID 5077622
Search Google for chemical match using the InChIKey NAGKYJATVFXZKN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone NAGKYJATVFXZKN
Search UniChem for chemical match using the InChIKey NAGKYJATVFXZKN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone NAGKYJATVFXZKN
Comments
The discovery of the so-called STING agonist G10 by high throughput in vitro screening is reported in [1]. However, the authors could find no evidence of direct G10 binding to STING, despite experiments showing it being essential for the antiviral effects of the compound. The identity of the protein or factor engaged by G10 which stimulates the STING-dependent response is still being investigated.