Compound class:
Synthetic organic
Comment: Structural studies have shown that thalidomide class immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, that is mediated by a glutarimide ring of the ligand. Binding of small molecules to cereblon can alter its substrate specificity [1]. Thalidomide and its related drugs enhance recruitment of Ikaros and Aiolos to the E3 ubiquitin ligase complex. CC-885 has a different mechanism of action compared to thalidomide, lenalidomide and pomalidomide. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism [2].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
3-(3-chloro-4-methylphenyl)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea |
Database Links | |
GtoPdb PubChem SID | 340590211 |
PubChem CID | 24788636 |
Search Google for chemical match using the InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | DOEVCIHTTTYVCC |
UniChem Compound Search for chemical match using the InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |