Classification
Compound class	Synthetic organic

IUPAC Name

3-(3-chloro-4-methylphenyl)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea

Comments

Structural studies have shown that immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, mediated by a glutarimide ring. The broad activity profile of CC-885 is highly differentiated from that of thalidomide, lenalidomide and pomalidomide. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism [1].

Database Links
GtoPdb PubChem SID	340590211
PubChem CID	24788636
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Search UniChem for chemicals with the same backbone	DOEVCIHTTTYVCC