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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
3-(3-chloro-4-methylphenyl)-1-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]urea |
Comments |
Structural studies have shown that immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, mediated by a glutarimide ring. The broad activity profile of CC-885 is highly differentiated from that of thalidomide, lenalidomide and pomalidomide. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism [1]. |
Database Links ![]() |
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GtoPdb PubChem SID | 340590211 |
PubChem CID | 24788636 |
Search Google for chemical match using the InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | DOEVCIHTTTYVCC |
Search UniChem for chemical match using the InChIKey | DOEVCIHTTTYVCC-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | DOEVCIHTTTYVCC |