lisofylline

Ligand id: 9225

Name: lisofylline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.67
Molecular weight 280.15
XLogP 0.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Prodrug pentoxifylline
IUPAC Name
1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
International Nonproprietary Names
INN number INN
7322 lisofylline
Synonyms
(R)-lisophylline | CT-1501R
Database Links
CAS Registry No. 100324-81-0
ChEMBL Ligand CHEMBL1411
PubChem CID 501254
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Comments
Lisophylline is an active metabolite of pentoxifylline. The compound has novel anti-inflammatory properties, likely through inhibition of IL-12 signalling and STAT-4 activation [2]. It is reported to prevent type 1 diabetes in preclinical models [3] and improve the function and viability of isolated or transplanted pancreatic islets [1]. Evidence suggests that combined treatment with lisofylline (for its anti-inflammatory action) and exendin-4 (to enhance beta-cell proliferation) can reverse autoimmune diabetes in the non-obese diabetic (NOD) mouse model [4].