PF-06767832

Ligand id: 9228

Name: PF-06767832

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 112.58
Molecular weight 409.15
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(3R,4S)-3-hydroxyoxan-4-yl]-5-methyl-4-[[4-(1,3-thiazol-4-yl)phenyl]methyl]pyridine-2-carboxamide
Database Links
PubChem CID 118663155
Search Google for chemical match using the InChIKey VVZZHFMLRHJXTO-RXVVDRJESA-N
Search Google for chemicals with the same backbone VVZZHFMLRHJXTO
Search UniChem for chemical match using the InChIKey VVZZHFMLRHJXTO-RXVVDRJESA-N
Search UniChem for chemicals with the same backbone VVZZHFMLRHJXTO
Comments
PF-06767832 (compound 38) is an orally bioavailable, positive allosteric modulator (PAM) selective for the M1 muscarinic acetylcholine receptor (CHRM1) [2]. It is one of the compounds claimed in patent WO2016009297 [1]. M1 receptor PAMs are being designed for their potential to provide novel therapies for the treatment of M1-mediated diseases and disorders such as Alzheimer's disease.