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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(2R)-4-(1-adamantyl)-N-[2-[4-[4-amino-3-[4-phenoxy-3-(prop-2-enoylamino)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethyl]-2-methylbutanamide |
Synonyms ![]() |
conjugate 2e [PMID: 26094118] |
Database Links ![]() |
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GtoPdb PubChem SID | 315661317 |
PubChem CID | 78243759 |
Search Google for chemical match using the InChIKey | GKJWHLDKQULMHJ-PZMWFESPSA-N |
Search Google for chemicals with the same backbone | GKJWHLDKQULMHJ |
Search UniChem for chemical match using the InChIKey | GKJWHLDKQULMHJ-PZMWFESPSA-N |
Search UniChem for chemicals with the same backbone | GKJWHLDKQULMHJ |
Comments |
TX2-121-1 is a functional analogue of TX1-85-1 [1]. It acts to inhibit HER3-dependent signalling and growth, likely due to the effect of the conjugated hydrophobic adamantine group which is believed to target HER3 for proteasome-mediated degradation. Targeted degradation reduces the amount of HER3 available to form the HER3 heterodimers believed to be required for cellular activity. |