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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
CGI-560 |
Database Links ![]() |
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BindingDB Ligand | 50388182 |
ChEMBL Ligand | CHEMBL2057914 |
GtoPdb PubChem SID | 315661339 |
PubChem CID | 11397050 |
Search Google for chemical match using the InChIKey | IJMHHZDBRUGXNO-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | IJMHHZDBRUGXNO |
Search UniChem for chemical match using the InChIKey | IJMHHZDBRUGXNO-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | IJMHHZDBRUGXNO |
Comments |
CGI560 is a potent, reversible Bruton's tyrosine kinase (BTK) inhibitor, that was tested preclinically for potential clinical utility in inflammatory diseases and B cell malignancies. Structure depicted in [1]. Hit-to-lead chemistry based on CGI560's structure resulted in the discovery of CGI1746, with improved potency and selectivity [1]. |