setmelanotide

Ligand id: 9272

Name: setmelanotide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
IUPAC Name
(4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide
International Nonproprietary Names
INN number INN
10011 setmelanotide
Synonyms
BIM-22493 | RM-493
Comments
Setmelanotide is an investigational agonist of melanocortin receptors, with approximately 20-fold selectivity for the melanocortin 4 receptor subtype [5]. Chemically it is an eight-amino-acid cyclic peptide, able to cross the blood-brain barrier when administered peripherally. Setmelanotide is being investigated for its anti-obesity potential.

HELM annotation : PEPTIDE1{[ac].R.C.[dA].H.[dF].R.W.C.[am]}$PEPTIDE1,PEPTIDE1,3:R3-9:R3$$$
INN record documents the sequence as N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2-8)-disulfide.
Database Links
GtoPdb PubChem SID 315661347
PubChem CID 11993702
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Search UniChem for chemicals with the same backbone HDHDTKMUACZDAA