verinurad

Ligand id: 9327

Name: verinurad

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.28
Molecular weight 348.09
XLogP 4.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[3-(4-cyanonaphthalen-1-yl)pyridin-4-yl]sulfanyl-2-methylpropanoic acid
International Nonproprietary Names
INN number INN
9938 verinurad
Synonyms
RDEA-3170 | RDEA3170
Database Links
CAS Registry No. 1352792-74-5 (source: WHO INN record)
PubChem CID 54767229
Search Google for chemical match using the InChIKey YYBOLPLTQDKXPM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YYBOLPLTQDKXPM
Search PubMed clinical trials verinurad
Search PubMed titles verinurad
Search PubMed titles/abstracts verinurad
Search UniChem for chemical match using the InChIKey YYBOLPLTQDKXPM-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YYBOLPLTQDKXPM
Comments
Verinurad (RDEA3170) is an investigational selective uric acid reabsorption inhibitor, functionally inhibiting the URAT1 (SLC22A12) transporter and being investigated for clinical efficacy in controlling uric acid levels in patients with gout. URAT1 is the renal transporter that regulates uric acid excretion from the body. Verinurad is structurally related to lesinurad (RDEA594), a URAT1 inhibitor already approved for treating hyperuricemia in gout.