verinurad   Click here for help

GtoPdb Ligand ID: 9327

Synonyms: RDEA-3170 | RDEA3170
Compound class: Synthetic organic
Comment: Verinurad (RDEA3170) is an investigational selective uric acid reabsorption inhibitor, functionally inhibiting the URAT1 (SLC22A12) transporter and being investigated for clinical efficacy in controlling uric acid levels in patients with gout. URAT1 is the renal transporter that regulates uric acid excretion from the body. Verinurad is structurally related to lesinurad (RDEA594), a URAT1 inhibitor already approved for treating hyperuricemia in gout.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 99.28
Molecular weight 348.09
XLogP 4.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
Isomeric SMILES N#Cc1ccc(c2c1cccc2)c1cnccc1SC(C(=O)O)(C)C
InChI InChI=1S/C20H16N2O2S/c1-20(2,19(23)24)25-18-9-10-22-12-17(18)16-8-7-13(11-21)14-5-3-4-6-15(14)16/h3-10,12H,1-2H3,(H,23,24)
InChI Key YYBOLPLTQDKXPM-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[3-(4-cyanonaphthalen-1-yl)pyridin-4-yl]sulfanyl-2-methylpropanoic acid
International Nonproprietary Names Click here for help
INN number INN
9938 verinurad
Synonyms Click here for help
RDEA-3170 | RDEA3170
Database Links Click here for help
CAS Registry No. 1352792-74-5 (source: WHO INN record)
GtoPdb PubChem SID 318164846
PubChem CID 54767229
Search Google for chemical match using the InChIKey YYBOLPLTQDKXPM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YYBOLPLTQDKXPM
Search PubMed clinical trials verinurad
Search PubMed titles verinurad
Search PubMed titles/abstracts verinurad
UniChem Compound Search for chemical match using the InChIKey YYBOLPLTQDKXPM-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YYBOLPLTQDKXPM-UHFFFAOYSA-N