JQEZ5

Ligand id: 9332

Name: JQEZ5

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 108.28
Molecular weight 542.31
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide
Synonyms
EZ-005 | JQ5 | JQE5 [1]
Database Links
PubChem CID 121322599
Search Google for chemical match using the InChIKey LQTWDAYNGMMHLV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LQTWDAYNGMMHLV
Search UniChem for chemical match using the InChIKey LQTWDAYNGMMHLV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone LQTWDAYNGMMHLV
Comments
JQEZ5 is a potent and selective inhibitor of the histone methyltransferase EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) [2-4]. A commonly identified somatic gain-of-function mutation in human EZH2 (Y646F), recapitulated in a mouse model (Y641F) induces tumourigenesis by massively redistributing repressive trimethylated Lys27 histone H3 marks, leading to altered repression and activation of polycomb-regulated loci.
JQEZ5 was developed at the Dana-Farber Cancer Institute and is openly available as a research probe.