KYT-0353

Ligand id: 9347

Name: KYT-0353

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 124.6
Molecular weight 471.08
XLogP 2.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid
Synonyms
COMPOUND-JP [US20160279103] [1] | JPH-203 | KYT0353
Database Links
CAS Registry No. 1037592-40-7
PubChem CID 24853505
Search Google for chemical match using the InChIKey XNRZJPQTMQZBCE-SFHVURJKSA-N
Search Google for chemicals with the same backbone XNRZJPQTMQZBCE
Search UniChem for chemical match using the InChIKey XNRZJPQTMQZBCE-SFHVURJKSA-N
Search UniChem for chemicals with the same backbone XNRZJPQTMQZBCE
Comments
KYT-0353 (JPH-203) is a potent and selective inhibitor of L-type amino acid transporter 1 (SLC7A5) [2], being investigated as an anti-cancer agent. Structurally it is a tyrosine analog.