FMK

Ligand id: 9358

Name: FMK

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 94.03
Molecular weight 342.15
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
FMK (covalent)
Database Links
BindingDB Ligand 50248765
CAS Registry No. 821794-92-7 (source: PubChem)
ChEMBL Ligand CHEMBL515414
PubChem CID 644243
Search Google for chemical match using the InChIKey IKLGYJACVCXYIL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IKLGYJACVCXYIL
Search UniChem for chemical match using the InChIKey IKLGYJACVCXYIL-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone IKLGYJACVCXYIL
Comments
FMK is an irreversible inhibitor of ribosomal protein S6 kinases (RSKs) [1]. It binds covalently to the regulatory C-terminal kinase domain of the enzyme, thereby inhibiting activation of the N-terminal kinase domain.