KU-0063794

Ligand id: 9360

Name: KU-0063794

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 93.07
Molecular weight 465.24
XLogP 2.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol
Synonyms
KU-63794 | KU0063794
Database Links
BindingDB Ligand 50310989
CAS Registry No. 938440-64-3 (source: PubChem)
ChEMBL Ligand CHEMBL1078983
PubChem CID 16736978
Search Google for chemical match using the InChIKey RFSMUFRPPYDYRD-CALCHBBNSA-N
Search Google for chemicals with the same backbone RFSMUFRPPYDYRD
Search UniChem for chemical match using the InChIKey RFSMUFRPPYDYRD-CALCHBBNSA-N
Search UniChem for chemicals with the same backbone RFSMUFRPPYDYRD
Comments
KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) [1]. It inhibits both mTORC1 and mTORC2 with an IC50 of ~10 nM.