BPKDi

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Ligands
BPKDi

Ligand id: 9370

Name: BPKDi

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	7
Hydrogen bond donors	3
Rotatable bonds	5
Topological polar surface area	96.17
Molecular weight	380.23
XLogP	2.05
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic

IUPAC Name
2-[2-(cyclohexylamino)pyridin-4-yl]-6-piperazin-1-ylpyridine-4-carboxamide

IUPAC Name

2-[2-(cyclohexylamino)pyridin-4-yl]-6-piperazin-1-ylpyridine-4-carboxamide

Synonyms
bipyridyl PKD inhibitor

Synonyms

bipyridyl PKD inhibitor

Comments
BPKDi inhibits all three protein kinase D isozymes at low nanomolar concentrations [1]. This tool compound has been used to show that PKD acts to phosphorylate class IIa histone deacetylases in cardiomyocytes during cardiac hypertrophy. Inhibition of this action by BPKDi suppresses cardiomyocyte hypertrophy.

Comments

BPKDi inhibits all three protein kinase D isozymes at low nanomolar concentrations [1]. This tool compound has been used to show that PKD acts to phosphorylate class IIa histone deacetylases in cardiomyocytes during cardiac hypertrophy. Inhibition of this action by BPKDi suppresses cardiomyocyte hypertrophy.

Database Links
BindingDB Ligand	50324323
CAS Registry No.	1201673-28-0 (source: PubChem)
ChEMBL Ligand	CHEMBL1214999
GtoPdb PubChem SID	328083472
PubChem CID	46901383
Search Google for chemical match using the InChIKey	XNWDRALEEPGBHB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone	XNWDRALEEPGBHB
Search UniChem for chemical match using the InChIKey	XNWDRALEEPGBHB-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone	XNWDRALEEPGBHB