GSK143

Ligand id: 9388

Name: GSK143

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 128.18
Molecular weight 342.18
XLogP 1.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-{[(3S,4S)-3-aminooxan-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide
Synonyms
compound 20 [PMID: 21903390]
Database Links
PubChem CID 124037380
Search Google for chemical match using the InChIKey KBPYMFSSFLOJPH-KGLIPLIRSA-N
Search Google for chemicals with the same backbone KBPYMFSSFLOJPH
Search UniChem for chemical match using the InChIKey KBPYMFSSFLOJPH-KGLIPLIRSA-N
Search UniChem for chemicals with the same backbone KBPYMFSSFLOJPH
SynPHARM 84009 (in complex with spleen associated tyrosine kinase)
Comments
GSK143 a potent, selective and orally active spleen tyrosine kinase (SYK) inhibitor [1] (compound 20 therein). It has favourable physicochemical properties including good aqueous solubility.