HG-10-102-01

Ligand id: 9392

Name: HG-10-102-01

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 88.61
Molecular weight 377.13
XLogP 0.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
compound 15 [PMID: 22591441]
Database Links
BindingDB Ligand 50396041
ChEMBL Ligand CHEMBL2170016
PubChem CID 58539301
Search Google for chemical match using the InChIKey YEVOZZZLKJKCCD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YEVOZZZLKJKCCD
Search UniChem for chemical match using the InChIKey YEVOZZZLKJKCCD-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YEVOZZZLKJKCCD
Comments
HG-10-102-01 is a brain-penetrant, selective small-molecule inhibitor of LRRK2 (leucine rich repeat kinase 2), activating mutations of which have been associated with Parkinson's disease [1]. An alternative stereoisomer is presented in [2].