ipragliflozin

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Ligands
ipragliflozin

Ligand id: 9394

Name: ipragliflozin

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	5
Hydrogen bond donors	4
Rotatable bonds	4
Topological polar surface area	118.39
Molecular weight	404.11
XLogP	3.57
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic
Approved drug?	Yes (source: Japan (2014))

IUPAC Name
(2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

IUPAC Name

(2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

International Nonproprietary Names
INN number	INN
9258	ipragliflozin

Synonyms
ASP-1941
ASP1941
Suglat®

Synonyms

ASP-1941

ASP1941

Suglat®

Database Links
BindingDB Ligand	50381554
CAS Registry No.	761423-87-4
ChEMBL Ligand	CHEMBL2018096
PubChem CID	10453870
Search Google for chemical match using the InChIKey	AHFWIQIYAXSLBA-RQXATKFSSA-N
Search Google for chemicals with the same backbone	AHFWIQIYAXSLBA
Search PubMed clinical trials	ipragliflozin
Search PubMed titles	ipragliflozin
Search PubMed titles/abstracts	ipragliflozin

Comments
Ipragliflozin is a selective and orally available sodium/glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor [2,4] (a 'gliflozin' family drug [1]) used to treat type 2 diabetes. In practice ipragliflozin is complexed with L-proline in a 1:1 ratio.

Comments

Ipragliflozin is a selective and orally available sodium/glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor [2,4] (a 'gliflozin' family drug [1]) used to treat type 2 diabetes. In practice ipragliflozin is complexed with L-proline in a 1:1 ratio.