fruquintinib

Ligand id: 9428

Name: fruquintinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 95.71
Molecular weight 393.13
XLogP 2.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
International Nonproprietary Names
INN number INN
10348 fruquintinib
Synonyms
HMPL-013 | HMPL013
Database Links
CAS Registry No. 1194506-26-7 (source: WHO INN)
GtoPdb PubChem SID 328083528
PubChem CID 44480399
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Comments
Fruquintinib (HMPL-013) is a potent and selective inhibitor of VEGFR 1, 2, 3 tyrosine kinases, being developed for potential antineoplastic efficacy [1]; preclinical data is reported in this reference.