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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(2R)-3-acetyl-1-(4-chloro-2-fluorophenyl)-2-cyclohexyl-4-hydroxy-2H-pyrrol-5-one |
Synonyms ![]() |
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analog 49 (Dasse et al., 2007) [1] |
Comments |
CCR2-RA-[R] is an allosteric antagonist of the CC chemokine receptor 2 (CCR2) [1]. Allosteric modulation by CCR2-RA-[R] prevents formation of the G-protein-binding interface and hence G-protein coupling by blocking the required activation-associated changes in receptor conformation [3]. The chemical structure presented here is that held with the PDB X-ray structure reported in [3]. CCR2-RA-[R] is claimed as chiral example 125 in patent US6936633 [4]. |
Database Links ![]() |
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GtoPdb PubChem SID | 328083531 |
PubChem CID | 12093170 |
RCSB PDB Ligand | VT5 |
Search Google for chemical match using the InChIKey | VQNLJXWZGVRLBA-MRXNPFEDSA-N |
Search Google for chemicals with the same backbone | VQNLJXWZGVRLBA |
Search UniChem for chemical match using the InChIKey | VQNLJXWZGVRLBA-MRXNPFEDSA-N |
Search UniChem for chemicals with the same backbone | VQNLJXWZGVRLBA |
SynPHARM | 84096 (in complex with CCR2) |