PF-06263276

Ligand id: 9432

Name: PF-06263276

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 126.92
Molecular weight 566.26
XLogP 4.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[6-(2-Ethyl-5- fl uoro-4-hydroxyphenyl)-1 H -indazol-3-yl]- 1,4,6,7-tetrahydroimidazo[4,5- c ]pyridin-5-yl-(5-piperidin-1-yl- pyrazin-2-yl)methanone
Synonyms
compound 2 [PMID: 27983835] | PF 0626327 | PF0626327
Database Links
PubChem CID 71495793
RCSB PDB Ligand 7GS
Search Google for chemical match using the InChIKey XDJGNPSZQSWJCV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XDJGNPSZQSWJCV
Search UniChem for chemical match using the InChIKey XDJGNPSZQSWJCV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XDJGNPSZQSWJCV
Comments
In vitro and in vivo potency, and the pharmacokinetic and safety profiles of PF-06263276 indicate suitability for inhaled or topical therapy to treat inflammatory diseases, such as COPD or psoriasis, through direct administration to the lungs or skin, thus avoiding any systemic effects of JAK inhibition [1]. There are two E/Z isomers as PubChem CID 122196621 and PubChem CID 71495793 but these are not resolved in the publication.