intepirdine

Ligand id: 9444

Name: intepirdine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 70.68
Molecular weight 353.12
XLogP 3.03
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-(benzenesulfonyl)-8-piperazin-1-ylquinoline
International Nonproprietary Names
INN number INN
10281 intepirdine
Synonyms
RVT-101 | SB-742457
Database Links
BindingDB Ligand 50318633
CAS Registry No. 607742-69-8 (source: WHO INN record)
ChEMBL Ligand CHEMBL1083390
PubChem CID 11256720
Search Google for chemical match using the InChIKey JJZFWROHYSMCMU-UHFFFAOYSA-N
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Comments
Intepirdine (RVT-101) is a 5-HT6 receptor antagonist [4] (called SB-742457 in this article). Developed by Axovant Science Ltd.
Phase 3 clinical trial results for RVT-101 are eagerly awaited given the reported failures of competitors' 5-HT6 receptor antagonists in Alzheimer's disease trials (e.g. Lundbeck's idalopirdine, and Pfizer's PF-05212377).