navamepent

Ligand id: 9463

Name: navamepent

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 66.76
Molecular weight 304.17
XLogP 2.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
propan-2-yl (5S,8E,10E,12R)-5,12-dihydroxypentadeca-8,10-dien-6,14-diynoate
International Nonproprietary Names
INN number INN
10241 navamepent
Synonyms
RX-10045
Comments
Navamepent (RX-10045) is a stable resolvin E1 analogue, that is being investigated for clinical efficacy in occular inflammation [3]. Chemically this is an isopropyl ester prodrug of resolvin E1 (an agonist of the chemerin receptor). The chemical structure is claimed in patent US20140275247A1 (as Example 1001) [2]. Findings from animal studies are reported in [1] and [4].
Database Links
CAS Registry No. 1251537-11-7 (source: WHO INN record)
GtoPdb PubChem SID 329968403
PubChem CID 46926878
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