navamepent

Ligand id: 9463

Name: navamepent

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 66.76
Molecular weight 304.17
XLogP 2.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
propan-2-yl (5S,8E,10E,12R)-5,12-dihydroxypentadeca-8,10-dien-6,14-diynoate
International Nonproprietary Names
INN number INN
10241 navamepent
Synonyms
RX-10045
Database Links
CAS Registry No. 1251537-11-7 (source: WHO INN record)
PubChem CID 46926878
Search Google for chemical match using the InChIKey ZVOCIIHCJJEFRQ-BHXBHYJPSA-N
Search Google for chemicals with the same backbone ZVOCIIHCJJEFRQ
Search PubMed clinical trials navamepent
Search PubMed titles navamepent
Search PubMed titles/abstracts navamepent
Search UniChem for chemical match using the InChIKey ZVOCIIHCJJEFRQ-BHXBHYJPSA-N
Search UniChem for chemicals with the same backbone ZVOCIIHCJJEFRQ
Comments
Navamepent (RX-10045) is stable resolvin E1 analogue, being investigated for clinical efficacy (Phase 2) in occular inflammation. Chemically this is an isopropyl ester prodrug of resolvin E1 (an agonist of the chemerin receptor). Findings from animal studies are reported in [1] and [2].