ONO-7300243

Ligand id: 9499

Name: ONO-7300243

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 76.07
Molecular weight 461.22
XLogP 7.37
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[4-[[(3,5-dimethoxy-4-methylbenzoyl)-(3-phenylpropyl)amino]methyl]phenyl]acetic acid
Synonyms
compound 17a [1]
Database Links
PubChem CID 66775043
Search Google for chemical match using the InChIKey WGABOZPQOOZAOI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone WGABOZPQOOZAOI
Search UniChem for chemical match using the InChIKey WGABOZPQOOZAOI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone WGABOZPQOOZAOI
Comments
ONO-7300243 is a selective lysophosphatidic acid receptor 1 (LPA1) antagonist with favourable in vivo efficacy (reducing intraurethral pressure) in rat models of benign prostatic hyperplasia, which in contrast to the α1-adrenoceptor antagonist tamsulosin used clinically in this condition, has no effect on blood pressure [1].