LLY-283

Ligand id: 9527

Name: LLY-283

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 126.65
Molecular weight 342.13
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
Database Links
PubChem CID 122669401
Search Google for chemical match using the InChIKey WWOOWAHTEXIWBO-QFRSUPTLSA-N
Search Google for chemicals with the same backbone WWOOWAHTEXIWBO
Search UniChem for chemical match using the InChIKey WWOOWAHTEXIWBO-QFRSUPTLSA-N
Search UniChem for chemicals with the same backbone WWOOWAHTEXIWBO
Comments
LLY-283 is a potent and selective SAM-competitive chemical probe for PRMT5 (protein arginine methyltransferase 5) developed in a collaboration between Eli Lilly and the Structural Genomics Consortium [1]. It is one of the chemical tools in the SGC's Epigenetic Probes Collection.