LLY-283

Ligand id: 9527

Name: LLY-283

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 126.65
Molecular weight 342.13
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
Comments
LLY-283 is a potent and selective SAM-competitive chemical probe for PRMT5 (protein arginine methyltransferase 5) developed in a collaboration between Eli Lilly and the Structural Genomics Consortium [1]. It is one of the chemical tools in the SGC's Epigenetic Probes Collection.
Database Links
GtoPdb PubChem SID 336446913
PubChem CID 122669401
RCSB PDB Ligand F5J
Search Google for chemical match using the InChIKey WWOOWAHTEXIWBO-QFRSUPTLSA-N
Search Google for chemicals with the same backbone WWOOWAHTEXIWBO
Search UniChem for chemical match using the InChIKey WWOOWAHTEXIWBO-QFRSUPTLSA-N
Search UniChem for chemicals with the same backbone WWOOWAHTEXIWBO