AF-219

Ligand id: 9540

Name: AF-219

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 164.82
Molecular weight 353.12
XLogP 0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
International Nonproprietary Names
INN number INN
10642 gefapixant
Synonyms
AF219 | MK7264 | MK‐7264
Comments
Gefapixant (MK‐7264, and formerly AF-219) is a P2X3 and P2X2/3 receptor antagonist. Experimenatl results have shown that gefapixant acts as a reversible allosteric antagonist, that exhibits preferential activity at closed channels.
A recent study in rodent models has provided evidence that supports investigation of gefapixant as a novel treatment for chronic sensitisation conditions [5].
Database Links
GtoPdb PubChem SID 336446926
PubChem CID 24764487
RCSB PDB Ligand AF9
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