GSK2656157

Ligand id: 9544

Name: GSK2656157

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 89.93
Molecular weight 416.18
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
Synonyms
compound 6 [PMID: 24900593] | GSK-2656157
Database Links
ChEMBL Ligand CHEMBL2441340
PubChem CID 53469059
Search Google for chemical match using the InChIKey PRWSIEBRGXYXAJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PRWSIEBRGXYXAJ
Search UniChem for chemical match using the InChIKey PRWSIEBRGXYXAJ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PRWSIEBRGXYXAJ
Comments
GSK2656157 is an optimised, ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), designed using the structural scaffold of GSK2606414 [2]. Preclinical evaluation is reported in [1].