oleclumab

Ligand id: 9596

Name: oleclumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10545 oleclumab
Synonyms
MEDI 9447 | MEDI-9447
Comments
Oleclumab (MEDI9447) is a monoclonal antibody targeting the ecto-5'-nucleotidase (CD73), which is being investigated for oncology use [1-2]. Functional studies show that MEDI9447 is a high affinity antagonistic mAb, showing non-competitive inhibition of CD73 hydrolysis of AMP[1]. Two modes of action are suggested: prevention of steric conformational change required for catalytic active state, and inter-CD73 dimer cross-linking.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Database Links
Specialist databases
IMGT/mAb-DB 729
Other databases
GtoPdb PubChem SID 340590226
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