programmed cell death 1 ligand 1

Ligand id: 9606

Name: programmed cell death 1 ligand 1

Abbreviated name: PD-L1

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Immune checkpoint modulators
Synonyms
B7 homolog 1 | B7-H1 | PDL1 | programmed death ligand 1
Comments
This is one of the ligands for the PD-1 receptor. It is a single-pass type I membrane protein. The PD-L1/PD-1 interaction is an established immune checkpoint. Both the ligand and receptor are targets for novel immuno-oncology therapeutics, as over-expression of either of these proteins is a mechanism used by tumour cells to evade immune detection and destruction. Already the target of approved immunotherapeutics in the form of monoclonal antibodies, small molecules targeting the PD-1/PD-L1 checkpoint are now in development to address the shortcomings associated with the current antibody therapies (including, poor susceptibility rate to single immune checkpoint pathway inhibitors, long half-life of antibodies and association with the development of adverse events, problems connected to the requirement for intravenous infusions) [2,10].
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CD274 CD274 molecule Human -
Database Links
CATH/Gene3D 2.60.40.10
Ensembl Gene ENSG00000120217 (Hs)
Entrez Gene 29126 (Hs)
GtoPdb PubChem SID 340590236
Human Protein Atlas ENSG00000120217 (Hs)
OMIM 605402 (Hs)
RefSeq Nucleotide NM_014143 (Hs)
RefSeq Protein NP_054862 (Hs)
UniProtKB Q9NZQ7 (Hs)