latanoprostene bunod

Ligand id: 9635

Name: latanoprostene bunod

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 19
Topological polar surface area 139.36
Molecular weight 507.28
XLogP 6.51
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
International Nonproprietary Names
INN number INN
9629 latanoprostene bunod
Synonyms
BOL-303259-X | NCX-116 | PF-3187207 | Vesneo (proposed trade name)
Database Links
CAS Registry No. 860005-21-6 (source: WHO INN record)
ChEMBL Ligand CHEMBL2364612
PubChem CID 11156438
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Comments
Latanoprostene bunod is a NO-donating analogue of the prostaglandin F2α agonist latanoprost (isopropyl ester) [3]. This compound benefits from the additive hypotensive actions of both the prostaglandin agonist and NO. Latanoprostene bunod is a novel pharmacological candidate being investigated for its ability to treat ocular hypertension [2,4].