Structure and Physico-chemical Properties
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Molecular properties generated using the CDK |
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Classification  |
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| Compound class | Synthetic organic |
| Approved drug? | Yes (FDA (2017)) |
| IUPAC Name |
| 4-nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate |
| International Nonproprietary Names |
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| INN number | INN |
| 9629 | latanoprostene bunod |
| Synonyms |
| BOL-303259-X | NCX-116 | PF-3187207 | Vyzulta® |
| Comments |
| Latanoprostene bunod is a NO-donating analogue of the prostaglandin F2α agonist latanoprost (isopropyl ester) [3]. This compound benefits from the additive hypotensive actions of both the prostaglandin agonist and NO. Latanoprostene bunod is the first NO-donating prostaglandin analogue to be granted FDA marketing approval [2,4]. |
| Database Links |
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| CAS Registry No. | 860005-21-6 (source: WHO INN record) |
| ChEMBL Ligand | CHEMBL2364612 |
| GtoPdb PubChem SID | 340590265 |
| PubChem CID | 11156438 |
| Search Google for chemical match using the InChIKey | LOVMMUBRQUFEAH-UIEAZXIASA-N |
| Search Google for chemicals with the same backbone | LOVMMUBRQUFEAH |
| Search PubMed clinical trials | latanoprostene bunod |
| Search PubMed titles | latanoprostene bunod |
| Search PubMed titles/abstracts | latanoprostene bunod |
| Search UniChem for chemical match using the InChIKey | LOVMMUBRQUFEAH-UIEAZXIASA-N |
| Search UniChem for chemicals with the same backbone | LOVMMUBRQUFEAH |
