Classification
Compound class	Synthetic organic
Approved drug?	Yes (FDA (2017))

IUPAC Name

4-nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate

International Nonproprietary Names
INN number	INN
9629	latanoprostene bunod

Synonyms

BOL-303259-X | NCX-116 | PF-3187207 | Vyzulta®

Database Links
CAS Registry No.	860005-21-6 (source: WHO INN record)
ChEMBL Ligand	CHEMBL2364612
GtoPdb PubChem SID	340590265
PubChem CID	11156438
Search Google for chemical match using the InChIKey	LOVMMUBRQUFEAH-UIEAZXIASA-N
Search Google for chemicals with the same backbone	LOVMMUBRQUFEAH
Search PubMed clinical trials	latanoprostene bunod
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Search PubMed titles/abstracts	latanoprostene bunod
Search UniChem for chemical match using the InChIKey	LOVMMUBRQUFEAH-UIEAZXIASA-N
Search UniChem for chemicals with the same backbone	LOVMMUBRQUFEAH

Comments

Latanoprostene bunod is a NO-donating analogue of the prostaglandin F2α agonist latanoprost (isopropyl ester) [3]. This compound benefits from the additive hypotensive actions of both the prostaglandin agonist and NO. Latanoprostene bunod is the first NO-donating prostaglandin analogue to be granted FDA marketing approval [2,4].