GDC-0077

Ligand id: 9636

Name: GDC-0077

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 111.71
Molecular weight 407.14
XLogP 1.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
Synonyms
GDC0077 | RG6114 | Ro7113755
Database Links
PubChem CID 124173720
Search Google for chemical match using the InChIKey SGEUNORSOZVTOL-CABZTGNLSA-N
Search Google for chemicals with the same backbone SGEUNORSOZVTOL
Search UniChem for chemical match using the InChIKey SGEUNORSOZVTOL-CABZTGNLSA-N
Search UniChem for chemicals with the same backbone SGEUNORSOZVTOL
Comments
GDC-0077 is a potent and selective, orally available PI3K-p110α (PIK3CA) inhibitor, with potential antineoplastic activity. It is example 101 in patent US20170015678 (where it is named (S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)propanamide) [1]. GDC-0077 is one of the agents in Genentech's oncology discovery pipeline.