proguanil

Ligand id: 9676

Name: proguanil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 88.79
Molecular weight 253.11
XLogP 2.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2000) in combination with atovaquone)
IUPAC Name
(1E)-1-[amino-[(4-chlorophenyl)amino]methylidene]-2-propan-2-ylguanidine
International Nonproprietary Names
INN number INN
418 proguanil
Synonyms
Bigumal® | chloroguanide | Paludrin®
Database Links
CAS Registry No. 500-92-5 (source: Scifinder)
ChEMBL Ligand CHEMBL1377
DrugBank Ligand DB01131
GtoPdb PubChem SID 348353635
PubChem CID 6178111
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Wikipedia Proguanil
Comments
Proguanil is a biguanide derivative that, once administered, is converted to the active metabolite cycloguanil. It is an antimalarial drug, used in combination with atovaquone or with chloroquine.
Proguanil is one of the antimalarials listed in the WHO 20th Essential Medicines List (2017).