cibinetide

Ligand id: 9677

Name: cibinetide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
IUPAC Name
(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid
International Nonproprietary Names
INN number INN
10264 cibinetide
Synonyms
ARA 290 | ARA-290 | PH-BSP | PHBSP
Comments
Cibinetide (ARA 290) is an engineered peptide that mimics the 3 dimensional structure of the helix B surface domain of erythropoietin (EPO). It is designed to bind selectively to the non-hematopoietic EPO receptor (sometimes referred to as the innate repair receptor or IRR), that is believed to be a heterodimer of EPOR and the cytokine family beta common receptor (βCR, CD131) [1-2]. Non-hematopoietic EPO ligands have potential tissue protective and anti-inflammatory actions [4-6,8-10]. The IRR is suggested to be a point of integration between the immune system and pain signalling (via nociception) [11].

HELM annotation is PEPTIDE1{[Glp].E.Q.L.E.R.A.L.N.S.S}$$$$
IUPAC Condensed structure is H-Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH.
Cibinetide is SEQ ID NO. 282 (and peptide ID) claimed in patent WO2009094172 [3].
Database Links
CAS Registry No. 1208243-50-8 (source: WHO INN record)
ChEMBL Ligand CHEMBL3545305
GtoPdb PubChem SID 348353636
PubChem CID 91810664
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