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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|(R)-39  | BI 653048 BS H3PO4  | BI-653048 | BI653048|
|BI 653048 is a "dissociated" glucocorticoid receptor (GR) agonist (displaying different transcriptional regulatory profiles between gene transrepression and transactivation). This type of drug is designed to reduce the unwanted side-effects common to traditional GR agonists [1-2]. It has favourable drug-like properties, but because it has reduced mouse functional transrepression potency it is not suitable for evaluation in standard preclinical mouse models. BI 653048 is synthesised as the phosphoric acid (H3PO4) cocrystal to optimise physicochemical properties, stability characteristics, solubility and bioavailability compared to the free form .
This ligand is one of the compounds available from Boehringer Ingelheim's opnMe molecular library.
|GtoPdb PubChem SID||348353674|
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