macimorelin

Ligand id: 9745

Name: macimorelin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 12
Topological polar surface area 144.9
Molecular weight 474.24
XLogP 2.53
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2017))
IUPAC Name
2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
International Nonproprietary Names
INN number INN
9073 macimorelin
Synonyms
AEZS-130 | AEZS130 | Aib-DTrp-DgTrp-CHO | EP-1572 | EP1572 | UMV1843
Comments
Macimorelin is a ghrelin peptidomimetic [2]. It is a growth hormone (GH) secretagogue. The approved drug is the acetate salt (PubChem CID 71526737)- we show the parent molecule in this entry.
Database Links
BindingDB Ligand 50125886
ChEMBL Ligand CHEMBL278623
GtoPdb PubChem SID 354702218
PubChem CID 9804938
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