lofexidine

Ligand id: 9868

Name: lofexidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 33.62
Molecular weight 258.03
XLogP 2.5
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (UK (1990), FDA (2018))
IUPAC Name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
International Nonproprietary Names
INN number INN
3766 lofexidine
Synonyms
BritLofex® | Lucemyra®
Comments
Lofexidine is a selective α2-adrenoceptor agonist [1]. The INN defines this drug as a racemic mixture of stereo isomers. We show the chemical structure without specified stereochemistry to represent the mixture. Oral lofexidine tablets contain the hydrochloride salt.
Database Links
BindingDB Ligand 50019646
CAS Registry No. 31036-80-3 (source: WHO INN record)
ChEMBL Ligand CHEMBL17860
DrugBank Ligand DB04948
GtoPdb PubChem SID 363894162
PubChem CID 30668
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