UFM24

Ligand id: 9878

Name: UFM24

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 64.99
Molecular weight 298.08
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Comments
UFM24 is a flavone extracted from the Annonaceae Uvaria flexuosa [2]. It exhibits anti-inflammatory effects that are mediated by inhibition of PDE4 cAMP phosphodiesterases in neutrophils. The anti-inflammatory activities (inhibition of superoxide anion generation and elastase release from human neutrophils in response to fMLP) of seco-cyclohexenes and cyclohexenes isolated from Uvaria flexuosa leaves are reported by Hsu et al. (2016) [1].
Database Links
BindingDB Ligand 50250570
ChEMBL Ligand CHEMBL464108
GtoPdb PubChem SID 363894172
PubChem CID 14372618
Search Google for chemical match using the InChIKey YLSUKCVZCXUJBF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YLSUKCVZCXUJBF
Search UniChem for chemical match using the InChIKey YLSUKCVZCXUJBF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YLSUKCVZCXUJBF