cortistatin A

Ligand id: 9885

Name: cortistatin A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 65.82
Molecular weight 472.27
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Synonyms
(+)-cortistatin A | 17-epi-cortistatin A
Comments
Cortistatin A is a steroidal alkaloid isolated from the marine sponge Corticium simplex. It is a high affinity inhibitor of several protein kinases, including ROCK, CDK8, and CDK11 [2]. It has anti-proliferative and anti-angoiogenic activities [1-2].
Database Links
GtoPdb PubChem SID 363894179
PubChem CID 11561907
RCSB PDB Ligand C1I
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