savolitinib

Ligand id: 9918

Name: savolitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 91.61
Molecular weight 345.15
XLogP 2.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine
International Nonproprietary Names
INN number INN
9935 savolitinib
Synonyms
AZD-6094 | AZD6094 | compound 28 [PMID: 25148209] | HMPL-504 | HMPL504 | volitinib
Comments
Savolitinib is a potent and selective, ATP-competitive mesenchymal-epithelial transition factor (c-Met) inhibitor that was designed for anti-cancer potential [1]. In this discovery report it was called volitinib, but the designated INN is savolitinib. Research codes are HMPL-504 and AZD6094.
Database Links
BindingDB Ligand 50023342
CAS Registry No. 1313725-88-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL3334567
GtoPdb PubChem SID 363894212
PubChem CID 68289010
RCSB PDB Ligand V0L
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