pCXCL8-1aa

Ligand id: 9938

Name: pCXCL8-1aa

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
Comments
This is a small peptide that mimics the glycosaminoglycan (GAG) binding domain found in the C-terminal α helix of the CXCL8 cytokine [2]. It competes with CXCL8 for binding to GAGs, and by interfering in this interaction, reduces CXCL8-mediated inflammatory responses (leukocyte activation and extravasation to inflammatory sites).
The archetypal GAG-binding motif on CXC chemokines takes the form XBBBXXBX (where B = a basic amino acid and X = any nonbasic amino acid) [3].
The reference article also describes small peptides that interfere with CCL5 and CXCL12γ GAG binding [2].
Chemokine interactions with GAGs localise the chemokines around cell surfaces and the extracellular matrix. This provides a guidance mechanism for leukocyte migration [4]. Disrupting this guidance mechanism is predicted to produce anti-inflammatory effects, by reducing the ability of pro-inflammatory cells to migrate to sites of inflammation in response to cytokine signals.
Database Links
GtoPdb PubChem SID 363894232
PubChem CID 134611883
Search Google for chemical match using the InChIKey WAKZDRBORDWUSJ-NXCVNOGKSA-N
Search Google for chemicals with the same backbone WAKZDRBORDWUSJ
Search UniChem for chemical match using the InChIKey WAKZDRBORDWUSJ-NXCVNOGKSA-N
Search UniChem for chemicals with the same backbone WAKZDRBORDWUSJ