KAF156

Ligand id: 9946

Name: KAF156

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 76.18
Molecular weight 411.19
XLogP 3.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
IUPAC Name
2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7-yl]ethanone
Synonyms
ganaplacide (proposed INN) | GNF156
Comments
KAF156 is an antimalarial drug candidate, under clinical development. It is the optimised lead for the imidazolopiperazines, a novel class of compounds identified from a phenotypic screen as having antimalarial activity [1].

Potential Target/Mechanism Of Action: As the precise mechanism of action of KAF156 is not yet known, we do not have a molecular target for this compound.
Database Links
CAS Registry No. 1261113-96-5 (source: Scifinder)
ChEMBL Ligand CHEMBL2058833
GtoPdb PubChem SID 374883833
PubChem CID 49856296
Search Google for chemical match using the InChIKey BUPRVECGWBHCQV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BUPRVECGWBHCQV
Search UniChem for chemical match using the InChIKey BUPRVECGWBHCQV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BUPRVECGWBHCQV
Wikipedia KAF156