avatrombopag

Ligand id: 9953

Name: avatrombopag

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 158.38
Molecular weight 648.15
XLogP 4.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2018))
IUPAC Name
1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
International Nonproprietary Names
INN number INN
9571 avatrombopag
Synonyms
AKR-501 [1] | Doptelet® | E5501 [4] | YM477
Comments
Avatrombopag is a second generation, small molecule, orally administered thrombopoietin receptor agonist [1]. It was discovered through its ability to mimic the action of endogenous thrombopoietin which is the primary physiological regulator of normal platelet production.
Database Links
ChEMBL Ligand CHEMBL2103883
DrugBank Ligand DB11995
GtoPdb PubChem SID 374883840
PubChem CID 9852519
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