dual sEH/FAAH inhibitor 11   Click here for help

GtoPdb Ligand ID: 10124

Synonyms: compound B-11 [WO2017160861] | example 28 [WO2017160861]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Inhibitor 11 was designed as a dual inhibitor of fatty acid amide hydrolase (FAAH) and soluble epoxide hydrolase (sEH), two enzymes that independently down-modulate inflammatory and neuropathic pain [2]. The structure-activity relationship exploration was initiated using the potent FAAH inhibitor PF750 (which is a weak sEH inhibitor). Inhibitor 11 is one of the chemical structures claimed in patent WO2017160861A1, specifically example 28 (B-11) [1]. Inhibitor 11 exhibits favourable target selectivity, pharmacokinetic properties and in vivo target engagement [2].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 63.69
Molecular weight 539.16
XLogP 6.92
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(N1CCC(CC1)Cc1cccc(c1)Oc1ccc(cn1)C(F)(F)F)Nc1ccc(cc1)OC(F)(F)F
Isomeric SMILES O=C(N1CCC(CC1)Cc1cccc(c1)Oc1ccc(cn1)C(F)(F)F)Nc1ccc(cc1)OC(F)(F)F
InChI InChI=1S/C26H23F6N3O3/c27-25(28,29)19-4-9-23(33-16-19)37-22-3-1-2-18(15-22)14-17-10-12-35(13-11-17)24(36)34-20-5-7-21(8-6-20)38-26(30,31)32/h1-9,15-17H,10-14H2,(H,34,36)
InChI Key LWLSVNFEVKJDBZ-UHFFFAOYSA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Fatty acid amide hydrolase Primary target of this compound Hs Inhibitor Inhibition 7.4 pKi - 2
⤷ pKi 7.4 (Ki 3.7x10-8 M) [2]
epoxide hydrolase 2 Primary target of this compound Hs Inhibitor Inhibition 8.3 pIC50 - 1
⤷ pIC50 8.3 (IC50 5x10-9 M) [1]
Fatty acid amide hydrolase Primary target of this compound Hs Inhibitor Inhibition 8.1 pIC50 - 1
⤷ pIC50 8.1 (IC50 8x10-9 M) [1]
epoxide hydrolase 2 Rn Inhibitor Inhibition 7.7 pIC50 - 2
⤷ pIC50 7.7 (IC50 1.8x10-8 M) [2]
epoxide hydrolase 2 Mm Inhibitor Inhibition 7.6 pIC50 - 2
⤷ pIC50 7.6 (IC50 2.7x10-8 M) [2]
Fatty acid amide hydrolase Rn Inhibitor Inhibition 6.5 pIC50 - 2
⤷ pIC50 6.5 (IC50 3x10-7 M) [2]
Description: Following a 60 min preincubation with inhibitor.
Fatty acid amide hydrolase Mm Inhibitor Inhibition 5.8 pIC50 - 2
⤷ pIC50 5.8 (IC50 1.4x10-6 M) [2]