fulvestrant

Ligand id: 1015

Name: fulvestrant

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 15
Topological polar surface area 76.74
Molecular weight 606.32
XLogP 10.61
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GPER Agonist Full agonist 7.0 pKi - 2
pKi 7.0 [2]
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Estrogen receptor-α Antagonist Antagonist 9.0 pKi - 1
pKi 9.0 (Ki 1.04x10-9 M) [1]
Estrogen receptor-β Antagonist Antagonist 8.9 pKi - 1
pKi 8.9 (Ki 1.39x10-9 M) [1]
Ligand mentioned in the following text fields