tamoxifen

Ligand id: 1016

Name: tamoxifen

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 371.22
XLogP 10.76
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
CYP3A4 2
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GPER Agonist Full agonist 6.0 pKi - 4
pKi 6.0 [4]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Maxi Cl- Activator (extracellular tamoxifen) - - - -
VRAC Channel blocker - - - -
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Estrogen receptor-α Agonist Agonist 7.8 pKi - 3
pKi 7.8 [3]
Estrogen receptor-α Antagonist Antagonist 7.8 pKi - 3
pKi 7.8 [3]
Estrogen receptor-β Antagonist Antagonist 7.2 pKi - 3
pKi 7.2 [3]
Estrogen receptor-β Agonist Agonist 7.2 pKi - 3
pKi 7.2 [3]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields