linoleic acid

Ligand id: 1052

Name: linoleic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 14
Topological polar surface area 37.3
Molecular weight 280.24
XLogP 7.87
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Natural/Endogenous Targets
Target
FFA4 receptor
Hepatocyte nuclear factor-4-α
Peroxisome proliferator-activated receptor-γ
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
15-LOX-2
15-LOX-1
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
FFA4 receptor Hs Agonist Full agonist 5.9 pEC50 - 1
pEC50 5.9 [1]
FFA1 receptor Hs Agonist Full agonist 4.4 – 5.7 pEC50 - 2,4-5
pEC50 4.4 – 5.7 (EC50 3.98x10-5 – 1.99x10-6 M) [2,4-5]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv2.1 Hs Activator - 5.6 pEC50 - 7
pEC50 5.6 [7]
Kv2.1 Hs Channel blocker - 5.1 pIC50 - 7
pIC50 5.1 [7]
TRPM8 Hs Channel blocker - - - -
K2P10.1 Hs Activator - - - - 6
[6]
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Peroxisome proliferator-activated receptor-γ Hs Agonist Full agonist 5.3 pKd - 3,10
pKd 5.3 [3,10]
Hepatocyte nuclear factor-4-α Hs Agonist Full agonist - - - 11
[11]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields