rosiglitazone

Ligand id: 1056

Name: rosiglitazone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 96.83
Molecular weight 357.11
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
FFA1 receptor Hs Agonist Full agonist 5.6 pEC50 - 3
pEC50 5.6 [3]
Selectivity at ion channels
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPC5 Hs Activator Activation 4.5 pEC50 - 6
pEC50 4.5 [6]
TRPM3 Hs Channel blocker - - - - 6
[6]
Selectivity at nuclear hormone receptors
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
Peroxisome proliferator-activated receptor-γ Hs Agonist Full agonist 7.4 pKd - 2,4,7
pKd 7.4 [2,4,7]
Peroxisome proliferator-activated receptor-γ Hs Agonist Agonist 6.9 pKi - 5
pKi 6.9 (Ki 1.2x10-7 M) [5]
Ligand mentioned in the following text fields