(-)-baclofen

Ligand id: 1064

Name: (-)-baclofen

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 213.06
XLogP 1.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GABAB receptor Rn Agonist Full agonist 8.5 pIC50 - 1
pIC50 8.5 [1]
GABAB1 Rn Agonist Full agonist 4.4 – 4.6 pIC50 - 2
pIC50 4.4 – 4.6 [2]