5-MeOT

Ligand id: 107

Name: 5-MeOT

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 51.04
Molecular weight 190.11
XLogP 1.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT7 receptor Rn Agonist Full agonist 8.8 – 9.2 pKi - 27-28
pKi 8.8 – 9.2 [27-28]
5-HT2A receptor Hs Agonist Full agonist 8.9 pKi - 18
pKi 8.9 [18]
5-HT7 receptor Hs Agonist Full agonist 8.3 – 9.5 pKi - 5,17,20
pKi 8.3 – 9.5 [5,17,20]
5-HT7 receptor Mm Agonist Full agonist 8.2 pKi - 26
pKi 8.2 [26]
5-HT2A receptor Rn Agonist Full agonist 8.1 pKi - 18
pKi 8.1 [18]
5-HT1D receptor Hs Agonist Full agonist 7.4 – 8.7 pKi - 15,21,31
pKi 7.4 – 8.7 [15,21,31]
5-HT2B receptor Rn Agonist Full agonist 8.0 pKi - 30
pKi 8.0 [30]
5-HT6 receptor Rn Agonist Full agonist 6.9 – 8.4 pKi - 8-9,24
pKi 6.9 – 8.4 [8-9,24]
5-HT1B receptor Hs Agonist Full agonist 7.3 – 7.5 pKi - 25,31
pKi 7.3 – 7.5 [25,31]
5-HT6 receptor Hs Agonist Full agonist 7.4 pKi - 19
pKi 7.4 [19]
5-HT2C receptor Hs Agonist Full agonist 6.7 – 7.8 pKi - 13
pKi 6.7 – 7.8 [13]
5-HT4 receptor Rn Agonist Full agonist 6.3 – 7.4 pKi - 1,10,14
pKi 6.3 – 7.4 [1,10,14]
5-HT4 receptor Mm Agonist Full agonist 6.6 pKi - 11
pKi 6.6 [11]
5-HT2C receptor Rn Agonist Full agonist 6.3 pKi - 16
pKi 6.3 [16]
5-HT4 receptor Hs Agonist Full agonist 5.6 – 6.8 pKi - 3,6-7,22-23,29
pKi 5.6 – 6.8 [3,6-7,22-23,29]
5-HT1F receptor Hs Agonist Full agonist 5.9 pKi - 2
pKi 5.9 [2]
5-ht1e receptor Hs Agonist Full agonist 5.5 – 6.2 pKi - 2,4,12,25
pKi 5.5 – 6.2 [2,4,12,25]