CGS-12066

Ligand id: 109

Name: CGS-12066

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 11.41
Molecular weight 334.14
XLogP 3.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT1D receptor Hs Agonist Full agonist 8.5 – 8.6 pKi - 2,5
pKi 8.5 – 8.6 [2,5]
5-HT1B receptor Hs Agonist Full agonist 8.1 – 8.7 pKi - 1,5
pKi 8.1 – 8.7 [1,5]
5-HT2B receptor Hs Agonist Full agonist 6.1 pKi - 3
pKi 6.1 [3]
5-HT6 receptor Rn Agonist Full agonist 6.1 pKi - 4
pKi 6.1 [4]
5-HT2C receptor Hs Agonist Full agonist 5.6 pKi - 3
pKi 5.6 [3]
5-HT2A receptor Hs Agonist Full agonist 5.4 pKi - 3
pKi 5.4 [3]