ABT-239

Ligand id: 1218

Name: ABT-239

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 40.17
Molecular weight 330.17
XLogP 5.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
H3 receptor Hs Antagonist Inverse agonist 9.4 pKi - 1
pKi 9.4 [1]
H3 receptor Rn Antagonist Inverse agonist 8.9 pKi - 1
pKi 8.9 [1]
H1 receptor Hs Antagonist Inverse agonist 5.8 pKi - 1
pKi 5.8 [1]
H2 receptor Hs Antagonist Inverse agonist 5.2 pKi - 1
pKi 5.2 [1]