cetirizine

Ligand id: 1222

Name: cetirizine

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View more information in the IUPHAR Pharmacology Education Project: cetirizine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 53.01
Molecular weight 388.16
XLogP 4.21
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In rodent studies, systemically administered cetirizine shows negligible brain penetration or binding to cerebral H1 receptors.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H1 receptor Antagonist Inverse agonist 8.2 pKi - 1
pKi 8.2 [1]
Ligand mentioned in the following text fields